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Thr Property Management Lp – CHARLOTTE, NC – January 26, 2021 – Stream Realty Partners (Stream), a national real estate services, development and investment company, and Herbert Management Group (HMC), an investment management firm, announced today that more than 100, ,000 square feet of office space was leased at The Grove in Charlotte during 2020, with Humana signing the most recent lease for 11,500 square feet. Centrally located within the University submarket, the office park consists of our buildings totaling 259.064 square feet.
Notable leases completed in 2020 include Cognizant’s 30,572 square foot lease renewal, GSA’s new lease for 25,108 square feet, Humana’s new lease for 11,53 square feet, 3 wicked 3 feet. lease renewal and Mosaic’s 4,633 square foot new lease. One of the determining factors in attracting and retaining tenants to the park was the major park-wide capital improvement program that brought new life to The Grove. The most recent renovation occurred at Grove 5, which included a complete lobby and common area refresh, as well as the addition of a tenant lounge within the building.
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“We are pleased that new tenants recognize The Grove’s attractive work environment following our improvements, and look forward to welcoming more tenants to the property in 2021,” said Brandon Cohen, Director at Herbert Management Corp.
Chemoenzymatic Methods For The Synthesis Of Glycoproteins
Located in the heart of University Research Park at the intersection of two major thoroughfares (W.T. Harris Boulevard and Mallard Creek Road), the park’s recent capital upgrades within a beautiful campus setting, combined with an unrivaled location in the middle of C harlotte’s major interstate with immediate access to a highly educated, ever-growing talent pool has made The Grove an attractive choice for office tenants of all sizes. Through 2020 alone, total occupancy in the park has increased from 67 to 86 percent, with more than 107,000 square feet of new offerings, renewals and expansions.
“We are thrilled to welcome the newest companies to The Grove and continue the great relationship with our existing tenants in the park,” said Bob Boykin, vice president in Stream’s Carolinas office. “The time, money and effort spent by ownership to improve the image and experience within the park has greatly helped to attract and retain these fantastic companies.”
Stream’s Boykin, Alex Olofson , Senior Associate, and Brittany Kowalski , Associate, are overseeing leasing efforts for the property. Open Access Policy Institutional Open Access Program Special Issues Guidelines Editorial Process Research and Publication Ethics Article Processing Costs Awards Testimonials
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A novel variant in superoxide dismutase 1 gene (p.V119M ) in Als patients with pure lower motor neuron presentation
Pdf) Prediction Of Soil Water Retention Properties After Stratification By Combining Texture, Bulk Density And The Type Of Horizon
By Claudia Ricci *, Fabio Giannini, Giulia Riolo, Silvia Bocci, Stefania Casali and Stefania Battistini
Received: 23 August 2021 / Revised: 25 September 2021 / Accepted: 26 September 2021 / Published: 29 September 2021
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disorder characterized by degeneration of motor neurons in the cerebral cortex, brainstem and spinal cord. Most cases of ALS occur sporadically, but 5-10% of patients have a family history of the disease. Mutations in the superoxide dismutase 1 gene (SOD1) have been found in 12-23% of familial cases and in 1-2% of sporadic cases. Currently, more than 180 different SOD1 gene variants have been identified in ALS patients. Here, we describe two apparently sporadic ALS patients carrying the same SOD1 c.355G>A variant, leading to the p.V119M substitution, which has not been previously described. Both the patients showed pure lower motor neuron phenotype. The former presented with the wing-bone syndrome, a rare ALS variant, characterized by progressive distal onset weakness and atrophy of the lower limbs, slow progression and better survival than typical ALS. The latter showed rapidly progressive upper and lower limb weakness, neither upper motor neuron nor bulbar involvement, and shorter survival than typical ALS. We provide an accurate description of the phenotype, and a bioinformatics analysis of the p.V119M variant on protein structure. This study can increase the knowledge about genotype-phenotype correlations in ALS and improve the approach to ALS patients.
Amyotrophic lateral sclerosis; SOD1 gene; new variant; p.V119M; pure lower motor neuron phenotype; bat variant; progressive muscle atrophy; phenotype-genotype correlation; modeling amyotrophic lateral sclerosis; SOD1 gene; new variant; p.V119M; pure lower motor neuron phenotype; bat variant; progressive muscle atrophy; phenotype-genotype correlation; modeling
Does Regional Anesthesia Reduce Complications Following Total Hip And Knee Replacement Compared With General Anesthesia? An Analysis From The National Joint Registry For England, Wales, Northern Ireland And The Isle Of Man
Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive and fatal neurodegenerative disease characterized by the degeneration of the motor neurons in the brain and spinal cord, leading to progressive weakness of bulbar, thoracic, abdominal and limbs. Classical ALS (“Charcot ALS”) is defined by the selective degeneration of both upper motor neurons (UMN) and lower motor neurons (LMN) [1]. Damage of UMN in the motor cortex causes hyperreflexia, extensor plantar response and increased muscle tone, while dysfunction of LMN in the brainstem and spinal cord leads to generalized weakness, hyporeflexia, muscle atrophy, muscle cramps and fasciculations [2].
In the early stages, symptoms can be very different. At presentation, most affected individuals show spinal onset, characterized by focal limb weakness that begins in a distinct region of the body and then propagates from this area to secondary sites [3]. On the other hand, bulbar onset accounts for about 25% of ALS cases and is typically characterized by slurred speech and difficulty swallowing. In most cases, limb symptoms occur within 1-2 years. During the course of the disease, most cases become generalized and show combinations of both LMN and UMN signs affecting spinal and brainstem regions [4]. Other brain functions, such as oculomotor and sphincter functions, are rarely involved. Behavioral, cognitive or executive impairments have been reported in more than 30% of cases, while frontotemporal dementia (FTD) is described in 20.5% of patients [5]. Cognitive impairments may precede or occur after the onset of motor symptoms. Approximately 3% to 5% of patients show cognitive or respiratory onset [6]. Death is mainly due to respiratory failure, and occurs 2–4 years after onset, although a poor prognosis is often associated with bulbar and respiratory onset [ 7 ]. In a small percentage of patients, the duration of the disease may be longer (≥10 years).
Different ALS phenotypes have been recognized with distinct clinical presentations, progression and prognosis. Some of them are characterized by a predominant or selective LMN presentation, with marginal or absent UMN dysfunction. These include phalangeal arm (FA), phalangeal leg (FL) and progressive muscular atrophy (PMA) phenotypes [ 4 , 8 ]. Among these is the braided leg syndrome, also known as the Pseudopolyneuritis or the Marie-Patrickios form of ALS, a rare condition (about 3-3.5% of all motor neurone disease cases) [9] characterized by distal and asymmetric onset weakness and wasting of the lower limbs, where the disease remains confined for a long time. Flap bone syndrome is thus described as an LMN variant, but UMN involvement may occur in the later stages of disease [10]. A slower progression and significantly better prognosis compared to more typical forms of ALS has been reported [10], with a median survival time of 5 to 6 years [11]. The longer FL is confined to the legs, the longer is survival [10]. The PMA phenotype is characterized by progressive LMN signs without clinical evidence of UMN involvement, although UMN signs may occur during the course of the disease. This phenotype represents ~5% of all motor neurone disease cases and is usually characterized by a relatively earlier age of onset,
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