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Guardian Property Management Branford Ct – With more than $1.3 billion in private funding disclosed over the past 6 years, a total public market valuation of nearly $40 billion, and more than a dozen first-in-class small molecules and biologics for intractable diseases, the biotech startups they call the Greater New. Haven hub man are making their mark, fast! In this blog, we present the landscape of small molecule drug discovery and development in one of the fastest growing stealth centers in the United States. Nearly 70% of all downtown biotech companies are located in the New Haven – Farmington – Guilford axis, a validation of the central role this axis plays as an epicenter. The cities of Branford, Stamford and Westport are also an emerging story in the center.
Figure 1. Cities driving biotech innovation in downtown Greater New Haven. The numbers represent actual companies in each city.
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Echoing a growing theme in the US biotech landscape, Greater New Haven’s story is no different; most of the startups founded in the last six years are developing cancer drugs, and accordingly, most of the funding goes to that. Approximately 25 percent of all biotech companies in the center have an oncology drug in the discovery or preclinical phase. The breadth of pioneering technologies spans targeted protein degradation, immunotherapy and AI-driven discovery platforms.
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Surprisingly, neurology and neurosciences are equally robust, accounting for 11 of the companies in the center. The technologies deployed target a wide range of neuropsychiatric diseases ranging from Parkinson’s disease to Alzheimer’s, stroke and traumatic brain injury.
Rare diseases, a legacy therapeutic area for the center, remain strong, even as the tide of innovation funding shifts toward oncology and neurology. 8 of the center’s startups focus almost exclusively on rare pediatric disorders.
Figure 2. Therapeutic areas covered by businesses in downtown Greater New Haven. The numbers represent companies with pipelines in each area.
In oncology, Science Park, New Haven-based Arvinas Inc is leading the way, driven by pioneering research in the emerging field of protein degradation. This clinical-stage biotech is harnessing targeted protein degradation to reimagine the possibilities of previously undruggable targets. With a pipeline that includes protein degraders and chimeras targeting proteolysis, Arvinas has diligently selected its indications that include some of the most difficult to treat solid tumors with large unmet medical needs. They include, but are not limited to, metastatic castration-resistant prostate cancer and metastatic estrogen receptor-positive breast cancer. Arvinas degraders are designed to take advantage of the body’s own natural protein elimination system to selectively and efficiently degrade and eliminate disease-causing proteins in these cancers. Arvinas’ advances have attracted the interest of biotech and pharmaceutical giants such as Genentech, Pfizer and Bayer Pharmaceuticals.
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Among oncology startups founded less than 4 years ago, Cybrexa Therapeutics leads the pack. With an ingenious tumor-targeting platform called ‘alphalex’, Cybrexa is quietly building new applications and combinations of existing cancer therapeutics using a targeted intracellular drug delivery approach whose mechanism of action is independent of antigens of surface For old experimental drugs that may have been shelved for a long time due to toxicity issues, Cybrexa can provide a new lifeline. The New-Haven-based biotech is reimagining the limits of toxicity in drug development. It remains to be seen whether this technology can fulfill its promise in the clinic.
At the nexus of biomedicine and artificial intelligence, AI Therapeutics announces a new generation of companies in downtown Greater New Haven. His deep learning is in combinatorial drug screening and genomics, with a laser focus on speed by skipping long R&D cycles. To achieve this, the Guilford-based biotech uses a proprietary artificial intelligence algorithm, aptly named “Guardian Angel” to predict new treatments for diseases with unmatched accuracy.
Farmington/Branford-based EvolveImmune Therapeutics and Greenwich-based Oncosynergy round out the select list of startups pioneering medical advances in immunotherapy and offering hope to patients. Let’s delve into the science, deals and brainpower behind it in upcoming blogs.
Figure 3. Companies with oncology drugs in their pipeline in the biotech hub of Greater New Haven. Most of the startups were founded in the last 7 years.
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In Neurology, BioHaven Pharmaceuticals is setting the bar high with category leadership in neuropsychiatric disorders. BioHaven is developing a broad class of agonists and inhibitors with commendable clinical and regulatory success to date. Its core platform is largely based on calcitonin gene-related peptide (CGRP) receptor antagonists, a class of drug candidates targeting the pain signaling pathway with the potential to transform the management of migraines and the pain. BioHaven is also harnessing the ubiquitous neurotransmitter glutamate to target impulse control disorders.
The newest group of clinical-stage neurology/neuroscience biotech companies is led by New Haven-based Aeromics Inc and BioXcel Therapeutics. Aeromics’ discovery engine is based on an application of water physiology and membrane biochemistry to mitigate symptoms of severe acute ischemic stroke by preventing brain swelling (cerebral edema) after a ischemic event. Its next-door neighbor, BioXcel, hopes to make a dent in the universe of neuropsychiatric and neurodegenerative disorders such as schizophrenia and dementia.
Yale University’s basic neuroscience research needs no introduction. However, biotech startups that build on this research and use it as a launching pad for drug development at home, in the university’s backyard, have long been elusive; without prejudice to licensing associations. If this emerging class of startups can pull it off and stay local, we may be seeing the birth of a neuroscience-based biotech powerhouse.
Figure 4. Companies with Neurology/Neuroscience drugs in their pipeline in the Greater New Haven biotech hub. Most of the startups were founded in the last 7 years.
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New Haven-based Rallybio is leading the next wave of rare disease companies, picking up where Alexion Pharmaceuticals left off. With a current preclinical pipeline targeting fetal and neonatal alloimmune thrombocytopenia and immunoinflammation, Rallybio seeks to build a broad portfolio of assets including small molecules, engineered proteins and antibodies. To date, Rallybio has secured $180 million in venture funding from companies including Canaan Partners, F-Prime and 5AM, giving it enough runway to catapult its lead compounds into the clinical stage.
Figure 4. Companies with rare disease drugs in their pipeline in the Greater New Haven biotech hub. Most of the startups were founded in the last 7 years.
37% of Connecticut biotech startups, as well as 44% of public therapeutic companies, originate from or are affiliated with Yale University, primarily through the Blavatnik Fund for Innovation and the Yale Entrepreneurial Innovation Fund Institute; received by the Yale Office of Cooperative Research (“OCR”). 13% of all private startups are from the University of Connecticut’s Technology Incubation Program (TIP), a percentage that is growing. It remains to be seen whether the hub can attract external companies; to date, only a handful of non-proprietary biotech companies have located their research and development or manufacturing operations in Connecticut.
It’s still early days for the Greater New Haven Center, but there’s no shortage of top-notch and potentially [serial optimist alert!] best-in-class drugs powered by impressive science. Many of these companies are clinical-stage biopharmaceuticals without approved drugs yet, but their promise is unmistakable. We hope you’ll take the long ride in the passenger seat with us as we watch this marathon race to the clinic unfold. The links below will connect you to other disability-related resources in Connecticut. They are categorized to help you quickly identify resources that may be useful. For publications, see the publications section of this tab. Click here to view our Disability Resource Directory. Each website link you click will open a new window.
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